Pharmafrontiers

Drug food Interactions

Medications which should be taken on an  EMPTY stomach
Alendronate (Fosamax)	Ampicillin	Astemizole	Bethanechol
Bisacodyl	Captopril (Take 1 hour before meals)	Cefibuten (Cedax)	Cilostazol (Pletal)
Demeclocycline	Dicloxacillin	Didanosine (Videx)	Etidronate (Didronel)
Felodipine (Plendil)	Indinavir (Crixivan)	Lansoprazole (take before eating)	Levothyroxine
loratadine (Claritin)	loracarbef (Lorabid)	Methotrexate	Moexipril (Univasc)
Mycophenolate (Cellcept)	Omeprazole Take before eating	Oxacillin	Penicillamine
Perindopril (Aceon)	Repaglinide (Prandin)	Rifampin	Rifabutin (Mycobutin)
Riluzole (Rilutek)	Roxithromycin (take at least 15 minutes before or after a meal)	Sucralfate (Carafate)	Sulfamethoxazole - trimethoprim (Bactrim)
Sulfadiazine	Tetracycline (Do not take with milk or other dairy products)	Tolcapone (Tasmar)	Zafirlukast (Accolate)
Zalcitabine (Hivid)

 

Medications which should be  Taken with FOOD
Allopurinol (take after meal)	Atovaquone (Mepron)	Augmentin	Aspirin
Amiodarone (Cordarone)	Baclofen (Lioresal)	Bromocriptine (Parlodel)	clofazimine (Lamprene)
Carvedilol (Coreg)	Carbamazepine (Tegretol)	Chloroquine	Cimetidine (Tagamet)
Cefpodoxime (Vantin)	Diclofenac (Voltaren_	Divalproex sodium (Depakote)	Doxycycline
Felbamate (Felbatol)	fenofibrate (TriCor)	Fiorinal	Fludrocortisone
fenoprofen	Griseofulvin	glyburide (take with breakfast)	Hydrocortisone
Hydroxychloroquine (Plaquenil)	Indomethacin	Iron preparations (Take between meals--if GI upset occurs take with food)	Itraconazole capsules
Ketorolac	Lithium	Metronidazole	Misoprostol (Cytotec)
methanamine	mebendazole	methylprednisolone	naltrexone
Naproxen	Nelfinavir (Viracept)	Nitrofurantoin	Niacin
Olsalazine	Perphenazine	Pentoxifylline	Pergolide
Piroxicam	Potassium salts	Prednisone	Procainamide
Ritonavir (Norvir)	Salsalate	Saquinavir	Sevelamer (Renagel)
Spironolactone	Sulfasalazine	Sulfinpyrazone	Sulindac
Ticlopidine	Tolmetin	Trazodone	Troglitazone
Valproic acid

 

Drug - grapefruit interactions:  Drugs which may exhibit increased serum concentrations based on this interaction
amiodarone	astemizole	alprazolam	atorvastatin
benzodiazepines	buspirone	carbamazepine	carvedilol
cerivastatin	cilostazol	clarithromycin	Clomipramine
codeine	cyclosporine	dapsone	dextromethorphan
diazepam	diltiazem	estrogens	erythromycin
felodipine	fentanyl	finasteride	haloperidol
indinavir	lercanidipine	lidocaine	lovastatin
midazolam	methadone	nelfinavir	nifedipine
nicardipine	nimodipine	nisoldipine	nitrendipine
ondansetron	paclitaxel	progestins	progesterone
quinidine	ritonavir	salmeterol	saquinavir
simvastatin	tacrolimus	trazodone	triazolam
vincristine	zaleplon	zolpidem
Note: there may be omissions on this list. Absence of a drug does not necessarily indicate that the drug lacks this potential interaction.

 

Warfarin - food Interactions

Management of Dietary Interactions and Vitamin K: dietary consistency is the key to maintaining a sustained, stable response during warfarin therapy. Patients should be aware of vitamin K content in common foods, particularly foods high in vitamin K (green leafy vegetables (broccoli, Brussel sprouts, turnip greens, kale, spinach, beet greens), Cauliflower , legumes, mayonnaise, canola and soybean oils), and should maintain a consistent amount of these foods in their diet. The following foods should be avoided or limited, since they also can effect warfarin therapy:  caffeinated beverages (cola, coffee, tea, hot chocolate, chocolate milk).

Alcohol intake greater than 3 drinks daily can increase the effect of Coumadin. As long as alcohol intake does not exceed 3 drinks daily, clotting times should not be affected. This amount of alcohol is present in 12 ounces of table wine or three 12  ounce beers. (Acute binges can raise INR. Chronic alcohol ingestion may decrease INR. )

Herbal supplements can affect bleeding time.  Coenzyme Q10 is an herbal supplement whose chemical structure is similar to vitamin K, so it has the potential to affect bleeding time.  Herbal teas: green tea, buckeye, horsechestnut, tonka, bean, meliot, and woodruff.  Other examples include: feverfew, garlic, and ginseng.  Herbal medications should either be avoided or used consistently while on warfarin therapy.

 

Courtasy: Globalrph