Useful Resources, Databases for Pharmaceuticals, Chemistry & Medicine

1) Major Chemical Database Collections

Chemical Abstracts Service (CAS)

http://www.cas.org/

Scientific Technical Databases (STN)

http://www.stn-international.de/

Vifapharm Databases

http://www.vifapharm.de/datenbank.htm

ChemLin Chemical Databases

http://www.chemlin.de/chemie/datenbanken.htm

Online Database Collection, University of Cincinnati

http://www.engrlib.uc.edu/selfhelp/alphlist.htm

2)Chemical Substances Search

Chemfinder

http://chemfinder.cambridgesoft.com/

ChemIDplus

http://chem.sis.nlm.nih.gov/chemidplus

Chemical Substances Search (Chemical Industry)

http://www.chemindustry.com/chemicals

Web related Servers / Chemistry and small Molecules

http://www.iucr.org/sincris-top/themes/chimie/

3) Synthesis

SPRESI (Storage and Retrieval of Chemical Structure Information) - Web, Infochem

http://www.spresi.com/

Organic Synthesis (OS)

http://www.orgsyn.org/

4) Analysis

Chromatography Online, Library4Science

http://www.chromatography-online.org/

Separations NOW - Resource for Chromatography

http://www.separationsnow.com/basehtml/SepH/1,1353,0-4-25555-0-25555-directories--0,00.html

Analytical Database Systems

http://www.limathon.com/

Chromatography, ChemicalAnalyis.com

http://www.chemicalanalysis.com/chromatography.htm

ASTEC USA

http://www.astecusa.com/

Agilent (HP)

http://www.home.agilent.com/agilent/facet.jspx?t=80030.k.1&cc=US&lc=eng&sm=g&pageMode=TM

Thomson Instrument Company

http://www.hplc1.com/index.html

SEDERLE

http://www.sedere.com/

Dionex

http://www.dionex.com/app/tree.taf?asset_id=9536

Metrohm

http://www.metrohm.ch/applications.html

CAMAG

http://www.camag.ch/index.htm

5) Spectral Data

Spectral Data, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan

http://www.aist.go.jp/RIODB/SDBS/sdbs/owa/sdbs_sea.cre_frame_sea

Spectral Libraries

http://www.acdlabs.com/products/spec_lab/exp_spectra/spec_libraries/

SDBS - Integrated Spectral Data Base System for Organic Compounds

http://www.aist.go.jp/RIODB/SDBS/menu-e.html

Thermo Galactic Spectra Online

http://spectra.galactic.com/

Spectral Database of Organic Compounds

http://www.lehman.cuny.edu/chem/chemlib.html

NMR-Shift Database

http://www.nmrshiftdb.org/

6) Reference Standards

List of Chemical Reference Substances (WHO)

http://www.who.int/medicines/organization/qsm/activities/qualityassurance/pharmacopea/icrs.doc

LGC Promochem

http://www.lgcpromochem.com/home/home_en.aspx

Chemical References

http://www.comar.bam.de/

The National Institute of Standards and Technology (NIST) Chemistry Web Book

http://webbook.nist.gov/chemistry/

7) Pharma & Medicine

Rx list: Internet Drug Index

http://www.rxlist.com/script/main/hp.asp

HERAT BURN

What is heartburn?

Despite its name, heartburn doesn't affect the heart. Heartburn is a burning feeling in the lower chest, along with a 

sour or bitter taste in the throat and mouth. It usually occurs after eating a big meal or while lying down. The feeling 

can last for a few minutes or a few hours.

What causes heartburn?

When you eat, food passes from your mouth down a tube (about 10 inches long in most people) called the 

esophagus. To enter the stomach, the food must pass through an opening between the esophagus and 

stomach. This opening acts like a gate to allow food to pass into the stomach.

Usually, this opening closes as soon as food passes through. But if it doesn't close all the way, acid from your 

stomach can get through the opening and into your esophagus. This is called reflux. Stomach acid can irritate the 

esophagus and cause heartburn.

 

When you eat, food passes from your mouth down a tube (about 10 inches long in most people) called the 

esophagus. To enter the stomach, the food must pass through an opening between the esophagus and 

stomach. This opening acts like a gate to allow food to pass into the stomach.

Usually, this opening closes as soon as food passes through. But if it doesn't close all the way, acid from your 

stomach can get through the opening and into your esophagus. This is called reflux. Stomach acid can irritate the 

esophagus and cause heartburn.

 

Tips on preventing heartburn

    * Place 6- to 9-inch blocks under the legs at the head of your bed to raise it.

    * Try to eat at least 2 to 3 hours before lying down. If you take naps, try sleeping in a chair.

    * Lose weight if you're overweight.

    * Don't overeat.

    * Eat high-protein, low-fat meals.

    * Avoid tight clothes and tight belts.

    * Avoid foods and other things that give you heartburn

Call your doctor if:

    * You have trouble swallowing or pain when swallowing.

    * You're vomiting blood.

    * Your stools are bloody or black.

    * You're short of breath.

    * You're dizzy or lightheaded.

    * You have pain going into your neck and shoulder.

    * You break out in a sweat when you have pain in your chest.

    * You have heartburn often (more than 3 times a week) for more than 2 weeks. 

GAUARV TANEJA (THE EMERGING PHARMACIST  )

What does it feel like to take anabolic steroids?

 Anabolic steroids have psychological as well as physical  effects.(1,2)  The steroid abuser is more likely to  experiences mood swings including euphoria and feelings of  violence, and suicidal tendencies than his or her peers of the same  sex and age.(2-7)  These effects appear to stop after steroids are   stopped, but it is unknown whether there is any permanent psychological  change because no long-term studies of steroid effects on personality   have been done.(8)  Some researchers think that the feelings of  euphoria, aggressiveness, and reduced fatigue caused by anabolic  steroids motivate steroid abusers to work out harder and more often  than their non-steroid-using counterparts.(4,7,9-11)  They believe  this is the real reason for increases in muscle mass by steroid  abusers.  High doses of steroids may alter a person's self-image  and produce changes in behavior.(2,10-12)  Weight-lifting steroid  abusers who were evaluated with a standardized psychological test  were found to have antisocial personality traits similar to those  of alcoholics.(2,3)  In one study, all but one subject described (roid Rage) "frequent episodes of temper outbursts, arguments, shouting or throwing  objects, and having urges to beat, injure or harm others. . .."(2)    Personality changes associated with anabolic steroid abuse have led to  violence and the deaths of innocent bystanders.(10,13)  In one review of  such cases, (10) a weightlifter on steroids abducted and  murdered a hitchhiker on impulse.(10)  Another steroid user  abducted a female store clerk on a whim and shot her when she tried  to escape.(10)  In a third case, a steroid abuser convinced  a friend to help him plant an explosive device under his former  fiancee's car.  Fortunately, she was unhurt when they detonated  it.(10)  In another case, a steroid abuser burglarized three  homes and set them afire, leading to $141,000 in property  damages.(14)  In each of these cases, there was no prior history of violence.   Personalities returned to normal when steroids were stopped.(10,14)

REFERENCES 1. Moore WV. Anabolic steroid use in adolescence. J Am Med Assoc 1988 Dec 16;260(23):3484-6. 2. Perry PJ, Andersen KH, Yates WR. Illicit anabolic steroid use in athletes - a case series analysis. Am J Sports Med 1990 Jul-Aug;18(4):422-8. 3. Yates WR, Perry PJ, Andersen KH. Illicit anabolic steroid use - a controlled personality study. Acta Psychiatr Scand 1990 Jun;81(6):548-50. 4. Wagner JC. Abuse of drugs used to enhance athletic performance. American Journal Of Hospital Pharmacy 1989 Oct;46:2059-67. 5. Brower KJ, Eliopulos GA, Blow FC, Catlin DH, Beresford TP. Evidence for physical and psychological dependence on anabolic androgenic steroids in 8 weight lifters. American Journal Of Psychiatry 1990 Apr;147(4):510-2. 6. Council on Scientific Affairs. Drug abuse in athletes. J Am Med Assoc 1988 Mar 18;259(11):1703-5. 7. Kibble MW, Ross MB. Adverse effects of anabolic steroids in athletes. Clinical Pharmacy 1987 Sep;6:686-92. 8. Yesalis CE, Wright JE, Bahrke MS. Epidemiological and policy issues in the measurement of the long term health effects of anabolic-androgenic steroids. Sports Medicine 1989 Sep;8(3):129-38. 9. Kashkin KB, Kleber HD. Hooked on hormones - an anabolic steroid addiction hypothesis. J Am Med Assoc 1989 Dec 8;262(22):3166-70. 10. Pope HG, Katz DL. Homicide and near-homicide by anabolic steroid users. Journal Of Clinical Psychiatry 1990 Jan;51(1):28-31. 11. Brooks RV. Anabolic steroids and athletes. Phys Sportsmed 1980 Mar;8(3):161-3. 12. Hays LR, Littleton S, Stillner V. Anabolic steroid dependence. Am J Psychiatry 1990;147(1):122. 13. Conacher GN, Workman DG. Violent crime possibly associated with anabolic steroid use. American Journal Of Psychiatry 1989 May;146(5):679. 14. Kleinman CC. Forensic issues arising from the use of anabolic steroids. Psychiatric Annals 1990 Apr;20(4):219-21. by Trent Tschirgi, R. Ph.