Time and Concentration Dependent Effect of Antibiotics

b-lactam antibiotics and Vancomycin . . . . . .................. are antibiotics that exhibit time-dependent inhibition of microorganism.

Aminoglycosides, Fluoroquinolones, Daptomycin, Metronidazole, Azythromycin, Ketolides.................................................concenrtation dependent inhition

of microorganisms by these antibiotics.

Macrolides, Clindamycin, Streptogramins, Tetracyclines, and Linezolid . . . . .. . . . . ... . . .. ...............................The third group includes drugs that are predominantly bacteriostatic and produce moderate to prolonged Post antibiotic effects. Because of their prolonged Post antibiotic effects, their efficacy is determined less by time and more by AUC once concentrations exceed the MIC.