Dengue fever vaccine in the pipeline

By Dr Ananya Mandal, MD

Australians researchers are moving towards producing the first ever vaccine for dengue fever, the potentially life-threatening infection spread by mosquitoes in the tropics. At present late stage clinical trials are underway for a vaccine that would protect against all four known strains of the disease. Participants are now being recruited in Perth, Adelaide and Brisbane.

According to Associate Professor Peter Richmond, from Perth's Telethon Institute for Child Health Research, participants would be injected with the vaccine and their blood later checked for protective antibodies. He said that this vaccine once developed would be a boon for South east Asia where the disease is a true menace. “There are more than two hundred million infections annually, that's the estimate, and a couple of million (infected people) get a very severe form of Dengue hemorrhagic fever…From a global perspective, having an effective vaccine is very important,” he said.

Considering world population, over fifty percent live in areas at high risk of dengue fever that is usually fatal in children and adults alike. It causes fever and severe headache, vomiting, muscle and joint pain and skin rash. Australia also has sporadic outbreaks of the infection both from travelers and in the northern Queensland range of its specific type of carrier mosquito.

The vaccine is developed and the trials are being sponsored by pharmaceutical company Sanofi Pasteur. The vaccine is expected in five years.

courtesy- http://www.news-medical.net/news/20100920/Dengue-fever-vaccine-in-the-pipeline.aspx